Abstract: Heterotic effects were studied over mid and better parents, for yield and primary yield components in 12 crosses of Gossypium hirsutum L. involving four indigenous varieties viz., CIM-1 100, CIM-443, VH-57 and CIM-444. Maximum heterotic effects were found in all these traits ranging from 2.05 to 8.83% and all the crosses showed approximately 55% of positive heterotic effects over mid parent values. Positive heterobeltiosis was estimated in plant height and seed index. The crosses showing fair degree of heterotic effects may be used as a selection criteria for further strengthening the cotton breeding programme.