Abstract: Botanical extracts of two plants having medicinal importance were tested for their insecticidal properties. The toxicities of myrrh extracts (oleo-resin or oil) and jojoba oil were studies against the last larval instar of both mosquito and house fly. The larvae of Culex pipiens were highly affected by the tested compounds in comparison with the larvae of Musca domestica. The effect of botanical extracts on larvae of mosquito showed LD50 100.55, 138.13 and 649.43 ppm for myrrh oleo-resin, myrrh oil and jojoba oil, respectively. The combination of jojoba oil with myrrh oil was only highly toxic on larvae of mosquito and has a synergistic effect with a co-toxicity factor 53.44. The botanical extracts of myrrh have strong mortal effect on the larvae of both vectors than the jojoba oil. The present study strongly confirms that myrrh extracts could be use safely to control certain vectors.