Abstract: Medicinally important wild plants (17) of Margalla hills Islamabad and Salt range of Pothowar were compared based on their vesicular arbuscular mycorrhizal (VAM) status. Statistical interpretation of the data indicated a significant difference between the results of vesicles, arbuscules and hyphal infection in plants of Margalla hills and Salt range area. The number of VAM spores recovered from the rhizospheric soils of both the areas was also significantly different. Soils analyses further revealed a significant difference for values of sand, silt, phosphorus, potassium, calcium carbonate and soil pH while clay and nitrogen contents were non-significant. The study concludes that wild plant have enormous ability to establish mycorrhizal association under stressed conditions particularly in the saline environment of Salt range, VAM root colonization emphatically reflects an adaptive mechanism of plants.