Abstract: The relative efficacy of hand weeding and six herbicides on the yield components and yield of wheat variety Inqalab 91 was studied. Hand weeding and herbicides significantly increased the number of fertile tillers, spike length, number of Spikelets per spike, number of grains per spike, 1000-grain weight, biological yield and grain yield. The herbicides application decreased the weed population. The grain yield corresponded with the weed mortality of the different treatments Buctril-M, Tolkan and Logran produced the highest grain yield and comparable with the hand weeding. Buctril-M was in turn statistically at par with all other herbicidal treatments but it out yielded the weedy check. All other herbicides could not produced higher yield from the weedy check, statistically. It is recommended from the data that Buctril-M is a herbicide of choice for controlling broad leaf weeds spectrum of D.I.Khan area.