Abstract: The results of the present study showed that administration of 13-cis-retinoic acid or retinol acetate for 6 weeks reduced the diameter of the seminiferous tubules in the testes of Gerbillus chessemani. Also, a decrease in the Leydig cell count was observed. However, the ratio of spermatogenesis was decreased only by 13-cis-retinoic acid administration. On the other hand the ratio of spermatogenesis, diameter of seminiferous tubules and number of Leydig cells were nearly normal in the experimental animals after 12 week of withdrawal treatment of drugs.