Abstract: One hundred and fifty-nine different strains of Salmonella species from human and non-human materials were isolated. The isolation was carried out according to standard methods and the identification was done by API 20E system. The isolates were typed to serological O groups using a slide agglutination test by polyvalent O antisera. All strains were exposed to eighteen different antibiotics following the disk diffusion method. Of the 159 strains, 48 showed resistance to one or more antibiotics. Strains isolated from chickens shared resistance to kanamycin, neomycin and trimethoprim. The strains from sheep shared resistance to tetracycline and the strains from humans shared resistance to trimethoprim. None of the strains were resistant to cyclosporins and amikacin. Various strains were also found to be resistant to other antibiotics.