Abstract: Comparative histochemical studies on the liver damage following infections with Schistosoma mansoni and Schistosoma margreborwiei have been reported after 42, 49, 77, 91, 105 and 119 days post-infection in definitive host mouse. The most significant changes were the increase of protein in the hepatocytes present in the dark zones appeared during infections in the liver. However, normal hepatocytes were positive for glycogen and it was considerably reduced around the granuloma. Some areas of the liver exhibited magenta/purple red in colour and secretory cells of bile ducts were also stained for glycogen. Acid mucopolysaccharide was negative in the hepatocytes but increased amount of ribonucleic acid was stained in normal and infected liver. The ferric irons and lipofuscin pigments were stained negative in the hepatocytes but in few areas of the liver some positive granules of these substances were visible.