Abstract: The present research investigation was aimed at determining the behavior of TSS, BOD5, COD, Oil and grease, phenols and ammonia of pharmaceutical wastewater under varied concentrations of polymers (alum and chlorine), in order to determine the effectiveness of polymers as coagulant aids. Wastewater samples were collected from the holding tank in plastic containers. Total suspended solids were removed from the wastewater by alum treatment and it was found that alum dose of 200 mg L–1 was sufficient to remove TSS from 458 to 23 mg L–1 (95% removal). Similarly BOD5 was also readily removed by the alum treatment, showing that alum dose of 300 mg L–1 was optimum, in achieving 89 percent removal. Although removal of COD was not easily obtained due to the complex chemical composition of the wastewater. Therefore, variable results in terms of COD removal were obtained. It was observed that COD removal efficiency was as low as 13-45 percent for 100 mg L–1 and for 200 mg L–1 lit was between 26-77 percent and for 300 mg L–1 it was found out to be 28-88 percent. Different volumes of chlorine (diluted bleach, 50:50, 25:75 and 15:85) were used in order to find out the optimum chlorine dose for further reduction of COD. The residual COD removal efficiency of 15 percent bleach at 30 ml/100 ml dose was found to be 71 percent. Similarly for 25 percent and 50 percent bleach it was found out to be 89 percent and 86 percent respectively (Based on average of six results). Similarly alum dose of 300 mg L–1 it was sufficient to remove 65 percent phenol within a contact time of 30 minutes depending upon the phenol concentration in the original sample. Similarly the effect of chlorine on alum treated wastewater was observed for residual phenol and ammonia removal and it was found that 25 percent bleach at 10 ml, 20 ml and 30 ml was effective in bringing phenol level down to acceptable level of 0.1 mg L–1 or less.