Abstract: The influence of the disease on various blood parameters was studied in 4-6 months old buffalo calves experimentally infected with coccidiosis. The oocysts of Eimeria species appeared in faeces on day 13th post infection with their peak counts on day 16th post infection. A significant decrease in TEC, PCV, Hb concentration, MCV, MCHC and lymphocytes and increase in ESR, TLC, eosinophils and neutrophils was observed as compared with control. No significant effect on eosinophils and monocytes was recorded.