Abstract: Background and Objectives: Drug resistance causes fungal infections such as dandruff, athlete`s foot and ring worm to become difficult to treat. The study was undertaken to investigate the antifungal activity and phytochemical composition of Dicerocaryum senecioides extracts as an alternative remedy in primary health care. Materials and Methods: Agar well diffusion test were used to assess the antifungal activity. Thin Layer Chromatography (TLC) was used to screen for the phytochemical composition of the crude extracts by visualizing the developed plates under the Ultra Violet light and staining with standard revealing agents. Results: Ethyl acetate extract showed the highest antifungal activity followed by dichloromethane, ethanol, aqueous and hexane extracts in respective order of decreasing activity. The Minimum Inhibition Concentrations (MIC) of ethyl acetate were 1.25, 2.50, 1.25 and 5.00 mg mL–1 while those for dichloromethane extract were 2.50, 1.25, 0.625 and 2.50 mg mL–1 for fungi strains Aspergillus flavus, Aspergillus niger, Fusarium oxisporum and Penicillium italicum, respectively. The TLC phytochemical profile of the ethyl acetate extract revealed the presence of 8 compounds while dichloromethane extract revealed 5 compounds. The phytocompounds observed include tannins, phenolics, flavonoids, carbohydrates, glycosides, saponins, alkaloids, terpenes and steroids. Conclusion: The present study shows that Dicerocaryum senecioides moderately polar and polar extracts consist of remarkable antifungal activity and significant amount of health benefiting phytocompounds therefore it is a good candidate for searching for lead compounds to develop new antifungal therapies to deal with drug resistant fungal strains.