Abstract: Background and Objective: Schistosoma mansoni (S. mansoni ) worms inhabit the portal triad which may affect the blood elements. The present study investigated the ameliorative effects of Nitazoxanide (NTZ) on some biochemical parameters in S. mansoni-infected mice. Materials and Methods: Swiss albino mice (n = 42) were used in this study and were divided into three groups. G1was normal (n = 6), 36 mice were infected with 100 S. mansoni cercariae were classified into two groups, G2 infected control group given only the vehicle (n = 18) and G3 was infected and treated with NTZ at a dose of 100 mg kg–1 for 7 days (n = 18). Treatment started 7 weeks’ post-infection by oral route. Blood samples were collected at 1, 2 and 4 weeks post treatment to obtain serum for liver functions (ALT, AST and ALP), kidney functions tests (blood urea and serum creatinine) and cholinergic function (serum cholinesterase level). Results: NTZ decreased significantly the elevated levels of liver enzymes, urea and creatinine in treated mice at 1, 2 and 4 weeks post treatment (WPT). NTZ caused significant elevation in the level of AChE at 2 and 4 WPT. Conclusion: Nitazoxanide was not only drastic but also showed some corrective action in biochemical parameters in S. mansoni-infected mice.