Abstract: The study was conducted to evaluate the efficacies of three different commercial anthelmintic containing triclabendazole and nitroxynil against fascioliasis in goat for a period of 28 days by using 20 goats. Among hundred goats, twenty goats were selected for this study which was suffering from liver fluke (Fasciola gigantica) infection and they were marked at the neck by tag. Twenty goats were randomly divided into four groups (A, B, C and D), where each group comprising of five goats. Goats of group A were treated with tablet fasinex (triclabendazole, Novartis Ltd, Bangladesh) orally at the dose rate of 12 mg kg–1 b.wt., group B were treated with acinex (triclabendazole, ACI Ltd, Bangladesh) orally at the dose rate of 12 mg kg–1 b.wt. and group C were treated with nitronex injection (nitroxynil, Renata Ltd, Bangladesh) subcutaneously at the dose rate of 10 mg kg–1 b.wt., Goats of group D was kept as infected control group without giving any treatment. A significant (p<0.01 and p>0.05) reduction of Egg Per Gram (EPG) count was found on 7th, 14th, 21st and 28th days of treated goats of group A, B and C respectively. The EPG count of control group were significantly (p<0.01 and p>0.05) increased 7 day onwards up to experimental period. Reduction of mean EPG on 7th, 14th, 21st and 28th day after treatment in group A, B and C were 81.48, 81.25 and 83.04%, respectively, whereas, in control group the mean EPG were 22.43%. Of the hematological parameters, TEC, Hb and PCV values were lower on day 0 but turned to increase (p<0.01 and p>0.05) on day 28 of the study. On the other hand, ESR and TLC were higher before treatment (day 0) but decreased significantly (p<0.01 and p>0.05) on day 28. The body weight was increased significantly (p<0.01 and p>0.05) after treatments in group A, B and C respectively except untreated control group D. This result may indicate that three different commercial anthelmintic contain triclabendazole and nitroxynil against fascioliasis in goat and nitroxynil have higher efficacies on Egg Per Gram (EPG), hematological parameters and body weight against fascioliasis in goat. Additional detailed studies are required to clarify the current status of the efficacy of the anthelmintic widely used in different agro ecologies, animal species and livestock management systems in Bangladesh.