Abstract: Background: This study was performed to evaluate the antibacterial activity and gastroprotective effect of methanol and ethyl acetate extracts of Emilia coccinae whole plant against ethanol-induced gastric mucosal injury in rats. Methodology: The antibacterial properties were examined using broth micro dilution method against 10 clinical strains of Helicobacter pylori. For the gastroprotective assessment, rats were divided into five groups, respectively pre-treated orally with vehicle (ulcer control groups), omeprazole 20 mg kg–1 (reference group), 250, 500 and 1000 mg kg–1 of E. coccinae (experimental groups) 1 h before oral administration of absolute ethanol to generate gastric mucosal damage. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. Results: The best antibacterial activity was recorded with E. coccinae methanol extract with MIC value of 64 μg mL–1 against 6 of the 10 (60%) tested strains. This results revealed that treatment with E. coccinae prior to absolute alcohol has significantly protect gastric mucosa as ascertained grossly by significant reduction of ulcer area, increases in gastric mucus production and decrease the acidity of gastric content compared to ulcer control group. Conclusion: Emilia coccinae was able to decrease the acidity of gastric content and increase gastric mucus production, there by justifying its use as an anti-ulcerogenic agent.