Abstract: Background and Objective: Vanillosmopsis arborea Baker (candeeiro) is a native plant from the Northeast of Brazil. Recently, this plant attracted interest of researchers due to its pharmacological properties, however, there is no underling mechanism established for its properties. So, the aim of this study was to investigate the antioxidant potential of this plant, since oxidative stress is in the core of the development of the diseases that V. arborea shows to be efficient in counteract. Materials and Methods: For this purpose, used aqueous extracts from bark, trunk and leaves for the plant, as well as the essential oil from the truck, in a set of oxidative stress models. Results: The main results obtained here demonstrate that aqueous extract from leaves are able to reduce Fe(II)-induced lipid peroxidation. However, when tested for iron chelation, none of the extracts shows any effect. For this reason, performed free radical scavenging test, by the quenching of 1’1’-diphenil-2-picrylhydrazyl (DPPH). It was observed that both aqueous extract from leaves and essential oil from the trunk were capable to scavenge free radical, indicating a direct effect of the plant on free radicals. Due to high (-)-α-bisabolol content in the essential oil and in the aqueous extract from leaves, hypothesized that this compound could be a central character in the antioxidant activity of the plant. So, performed a 2’7’-dichlorodihydrofluorescein diacetate (DCFH-DA) oxidation test with the essential oil and the (-)-α-bisabolol, which confirm the suggestion that (-)-α-bisabolol could be a major responsible for the antioxidant activity of V. arborea. Conclusion: Thus, V. arborea Baker could be considered an effective agent in the prevention of various diseases associated with oxidative stress and (-)-α-bisabolol is suggested to have prominent role in the plant properties.