Abstract: Bergamot is a citrus fruit, typical of Calabria and produced in the narrow strip of the Reggio Calabria’s coast. It is appreciated for its cosmetic properties, although it was sometimes used for its antiseptic and antibacterial action in ophthalmology, gynecology and dermatology. The discovery of its hypolipidemic and hypoglycemic activity is recent. Bergamot helps to control cholesterol and triglyceride levels. It also exerts antioxidant actions on the endothelium. Bergamot essential oil may represent a viable alternative for all those patients who are suffering from side effects of statins or cannot reach the therapeutic target for the pharmacological treatment, thanking to its high content in phenols and its lipid-lowering and glucose-lowering properties. The anti-oxidant properties can ameliorate endothelial cardiovascular disorders.