Abstract: Background: ET-1 is known to be implicated in various neurodegenerative diseases, including multiple sclerosis and Alzheimer’s disease. However, till date, there has been little, if any, investigation into its possible involvement in Parkinson’s Disease (PD). Results: Recent findings implicate ET-1 in the induction of Endoplasmic Reticulum (ER) stress in disease. ER stress has also been demonstrated to be an important factor in PD pathology and recent findings also indicate increased ET-1 levels in PD. Conclusion: The following review attempts to highlight the potential link between ET-1-induced ER stress and PD pathology.