Abstract: Background: Anemia is widely distributed among adolescent girls. This turned into multiple programmes to fight under nutrition anemia. A detailed times past followed by constitutional treatment by a fine and skilled homoeopathic understanding is necessary to treat the complaints that come into sight during adolescence especially in anemia. The present investigation was carried to see the efficacy of Ferrum Phos 3X alone and along with homeopathic constitutional medicines on hemoglobin level in adolescent girls. Materials and Methods: This interventional randomized open labeled parallel group study was conducted at Bharati Vidyapeeth Kanya Prashala, in Pune city. Adolescent age groups (10-18 years) with hemoglobin levels less than 12 g % were included in this study. The data of ‘hemoglobin percentage’ was analyzed using students “t” test; paired “t” test was applied for post hoc analysis. Results: The significant difference (p<0.05) was found in the hemoglobin percentage of the study subjects before treatment of the Ferrum Phos 3X and constitutional medicine as compared to the study subjects in the control group. Conclusion: Phosphorus was found to be one of the frequently administered constitutional remedy depicting a possible genus for anemic woe.