Abstract: Background: The aim of the present work is to synthesize a new series of thiophenes, thiadiazoles and pyrazoles by convenient and facile method with hope to discover more potent drugs as antidepressants and antifungi. Materials and Methods: The synthesized compounds were synthesized by two alternative methods. The targeting compounds were tested as antidepressant and antifungi by using male albino mice (20-24 g) in the forced swimming test under standard conditions with free access to food and water and agar-diffusion method, respectively. Results: The synthesized compounds could be considered as valuable templates for further modification or derivatization to design more potent antidepressant agents. The findings of this study illustrate that thiadiazole cycles of 13a-c exhibit more potency as antidepressants and antifungi than their analogous which contain thiophenes and pyrazole ring. Conclusion: Reactivity of the synthesized compounds vary according to the newly cyclized ring. As number of heteroatoms increase inside the ring especially sulfur atom, reactivity increases. Also, as electron withdrawing group increases, reactivity increases.