Abstract: Background: Presently medicinally important plants are the important safe therapeutic weapon to fight pain, pyrexia and inflammation, in which Schima wallichii is showing interest for their reported biological activities in indigenous system of medicine. Objective: To evaluate the analgesic, antipyretic and anti- inflammatory activity of different fractions of Schima wallichii barks. Material and Methods: The analgesic activity of Schima wallichii fractions (FPet.ether, FChloroform and FEthylacetate) was studied by using acetic acid induced analgesia and hot plate method in mice. The antipyretic activity of the fractions was studied in Brewer’s yeast induced pyrexia in rats. The anti-inflammatory activity was estimated volumetrically by measuring the mean increase in hind paw volume of rat using plethysmometer by inducing carrageenan. Results: FChloroform and FEthylacetate significantly decreased (p<0.05 and 0.01, respectively) the writhing in mice where FEthylacetate fraction persisted the action to increase the retention time in hot plate from 27±1.09 to 65±0.83% up to 120 min. The experimental results were comparable with the standard drug morphine sulphate. FEthylacetate fraction reduced the swelling of hind paw in inflammatory rats from 1 h to 3 h of carrageenan injection because of decrease in percentage increase of paw volume. The antipyretic study revealed the bioequivalence of FEthylacetate with paracetamol in respect of antipyretic activity at the time period of 15-30 h of drugs administration. Therefore; isolated flavonoid enriched Schima wallichii fraction FEthylacetate exhibits anti-inflammatory, analgesic and antipyretic activities which may be due to its association with direct or indirect inhibition of prostaglandins because all inflammatory responses are due to increase in prostaglandin levels that results in pain, swelling and fever.