Abstract: Background: Tetrapleura tetraptera (Schumach and Thonn) Taub stem bark is used in African folk medicine to treat hypertension. In the present study, the antihyperlipidemic and antioxidant effects of Tetrapleura tetraptera aqueous extract was investigated in high salt-sucrose-induced hypertensive rats. Methods: Hypertensive rats were obtained from normotensive Wistar rats by giving daily, 2 mL/100 g salt solution (9%) p.o., with free access to sucrose solution (10%) as drinking water. Another set of rats were divided into three groups of five rats each and treated respectively with salt-sucrose and the aqueous extract of Tetrapleura tetraptera (100 and 200 mg kg-1) or captopril (20 mg kg-1). The effects of plant extract were evaluated after 3 weeks on blood pressure, lipid profile, oxidative status and liver function of animals and compared to those of normotensive control rats. Blood pressure was evaluated by invasive method and biochemical parameters were evaluated by colorimetric and kinetic methods. Results: Chronic salt-sucrose consumption increased systolic arterial blood pressure (30.05%) and heart rate (15.36%) as compared to control. Tetrapleura tetraptera aqueous extract (100 and 200 mg kg-1) or captopril significantly prevented the increase in blood pressure and heart rate and inhibited salt-sucrose-induced lipid peroxidation in the liver. Tetrapleura tetraptera countered salt-sucrose induced oxidative stress by enhancing the activity of antioxidant enzymes (catalase, superoxide dismutase) and glutathione content. The plant extract significantly reduced the high concentration of serum Total Cholesterol (TC), glucose, triglyceride (TG) and low density lipoprotein (LDL-C) and increased high density lipoprotein (HDL-C) observed in salt-sucrose hypertensive rats. Tetrapleura tetraptera also prevented the increase in atherogenic index. Conclusions: these finding supports the traditional use of Tetrapleura tetraptera extract and suggested that the bark of this plant could protect from salt-sucrose damage by enhancing activities of enzymes and holding up the increase of lipid markers and membrane peroxidation.