Abstract: Back ground: Gastro Esophageal Reflux Disease (GERD) is a common disorder, affecting approximately 10-20% of the western population and often has a debilitating effect on the daily lives of patients. Result: GERD can be described as any symptomatic condition or histopathologic alternation resulting from episodes of gastroesophageal reflux. Transient relaxation of the lower oesophageal sphincter is believed to be the primary mechanism of the disease although the underlying cause remains uncertain. GERD usually manifests as heartburn, regurgitation, or dysphagia and predisposes to development of esophagitis, stricture, Barrett’s metaplasia, esophageal adenocarcinoma. The various agents currently used for treatment of GERD include proton pump inhibitors, antacids, H2-blockers, mucoprotective substances and prokinetic agents. Conclusion: This review gives an overview of the pharmacological management of GERD and summarizes the state of the art with these agents.