Abstract: Objective: The main objective of the current study was to figure out the influence of MTR instrumental variables on the pellets quality and performance. Materials and Methods: The current study also compared between hand-made granules and pellets using wet granulation. In addition, a formula composed of Avicel PH-101 and dibasic calcium phosphate (90:10 % w/w) was selected for studying the ability to scale up and possibility of transfer form MTR to larger mixer types. Results: It has been shown that the hand-made granules showed the faster drug release within 20 min which may be related to their non compacted nature and higher porosity. The maximum torque was in direct proportion with the mixing speed (rpm) value of MTR rotating blades. Pellets made of binder solution volume constituting the maximum torque position were of high quality. It has been shown that increasing binder volume led to decreasing friability of pellets and hand-made granules. Results showed that increasing binder volume during wet massing led to decreased pellets particle size and decreased friability. The decreased flowability of hand-made granules may be attributed to the scaly nature of their morphology which might increase the friction to each other. It has been shown that surface roughness of pellets was increased as binder volume increased. Scaling up from 30 to 500 and 1000 g was highly successful confirming suitability of MTR as a preformulation tool.