Abstract: Salmonella contamination in shrimp is a matter of concern nowadays in Bangladesh. The present study was aimed at investigating the occurrence of Salmonella and their antibiotic resistance pattern in shrimp from different markets in Dhaka city. A total of 105 shrimp samples were collected from randomly selected markets. Salmonella was detected by conventional methods. All Salmonella isolates were subjected to antimicrobial susceptibility testing and plasmid profiling. The prevalence of Salmonella was found very low (n = 6, 5.71%). After detailed biochemical and serological characterization, the isolates were identified as Salmonella enetrica subspp. Salamae (A4), Salmonella bongori (G3), Salmonella enterica subspp typhi (J3), Salmonella enterica subspp. enterica (K4), Salmonella enterica subspp. houtenae (O3) and Salmonella enterica subspp. arizonae (T5). All isolates were susceptible to chloramphenicol, ciprofloxacin and doxycycline. The highest resistance was found to ampicillin (100%) followed by erythromycin (83.33%), gentamicin 33.33%), nitrofurantoin (16.67%) and nalidixic acid (16.67). Plasmid profiles showed the presence of small plasmids of 3.4 to 1 Kbp in all isolates. The results suggest that shrimps consumed in Dhaka city may be contaminated with multi-drug resistant plasmid-harboring Salmonella.