Abstract: This study was established to investigate the toxic effects of potassium dichromate on sex hormones of female albino rats and the possible protective effects of rice bran oil. This study was carried out on thirty weanling mature female albino rats weighing between 120 and 140 g, divided randomly into 3 groups. Rats in the 1st group were used as a control (group C ), the 2nd group of rats (group E) received Potassium dichromate (20 mg kg-1, I/P) for 5 months, while the 3rd group, group B, received both Potassium dichromate solution (20 mg kg-1, I/P) and rice bran oil (20 mg kg-1), with 1 h in between for 5 months. Blood samples were collected from retro orbital venous sinus in lithium heparin tubes every 30 days. Sexual hormones were determined by ELISA technique. The study showed that potassium dichromate affects the levels of sex hormones and that the rice bran oil has great effects in the prevention of the toxic effects of potassium dichromate on sex hormones.