Abstract: The plant Cuscuta californica was traditionally used to treat liver, spleen and gallbladder disorders such as jaundice and to support liver function in other Western herbalism. The present study was conducted to evaluate hepatoprotective effect of methanolic extracts of Cuscuta californica at doses of 100, 200 and 400 mg kg-1 day-1 and aqueous extract at dose 400 mg kg-1 day-1 orally for 5 days against carbon tetrachloride (CCl4)- induced liver damage in rats. After injection of CCl4 on 3rd day and administration of 100 mg kg-1 methanol extract for 5 days slightly increased the liver enzymes and decreased bilirubin concentration. At 200 and 400 mg kg-1 methanol extract and 400 mg kg-1 aqueous extract there was a damage and necrosis in the liver. The characteristic trait of extracts of plant is its toxicity on liver, kidney and changes on growth rate. This toxicity was accompanied by increase in the activity of aspartate transaminase (AST), alkaline phosphatase (ALP) and alanine transaminase (ALT), decreased concentration of albumin in serum and granulocytes and increased value of lymphocytes in blood. This study revealed that the plant C. californica did not showed any hepatoprotective activity but slight hepatotoxicity to the treated animals.