Abstract: In the present study Acacia catechu-Catechin (CTN) was evaluated for antiamnesic and antioxidant activity using various in vivo models. Scopolamine and natural aging were used to induce experimental amnesia in mice. The tested does of CTN (40, 20 and 10 mg kg-1) significantly enhanced the learning capacity and retention of memory in Passive Shock Avoidance and Spatial Water cage exteroceptive behavioural models. Pre-treatment with CTN restored the increased levels of lipid peroxidation and reduced glutathione due to scopolamine and natural aging. A dose dependent CTN (40, 20 and 10 mg kg-1) antioxidant activity of Thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) in whole brain was seen, which were comparable to Standard Piracetam (400 mg kg-1). Hence, it is worthwhile to explore the potential of this Acacia catechu-Catechin in the management of Neurodegenerative disorders of the type Alzheimer’s disease.