Abstract: The present study was planned to elucidate the role of zinc in the modification of toxicity of cadmium with emphasis on vital organ dysfunction. Eighty, 3-months old male Wistar rats were fed cadmium chloride (CdCl2) and Zinc chloride (ZnCl2) mixture for 6 or 12 weeks. Group 2 (10 ppm CdCl2 + 4 ppm ZnCl2), group 3 (100 ppm CdCl2 plus 100 ppm ZnCl2) and group 1 was kept as control rats. The rats fed diet containing 10 ppm CdCl2 plus 4 ppm ZnCl2 of this mixture had the lowest growth rate after 12 weeks, but none of the rats died along the experimental period. Depression in growth, nephropathy, testicular injury and reduction in the size of the splenic white pulp were observed in group 2 and 3. Changes in serum alanine aminotransferase (ALT), aspartate aminotranferase (AST) and alkaline phosphatase (ALP) activities were significant increased in group 2 and 3. Alteration in concentration of total protein, albumin, cholesterol and urea were observed within these two treated groups. At 12 weeks, the values of erythrocytic series in rats of group 2 and 3 did not change. However, the values of platelets were higher in rats in group 2 and 3 then control (group 1). The values of WBC were higher in group 2 than control and group 3 and those of lymphocytes were lower in group 2 and 3 than control rats (group 1). The result indicated that Zn did not reverse the negative effects of Cd in growth and in organs damage particularly the kidneys, testes and spleen. This damage probably contributed to the increase in AST, ALT and ALP activities and cholesterol and urea concentrations with decrease in total protein and albumin concentrations.