Abstract: The effect of Aspirin (ASA) and indomethacin (Indocin) on the histomorphology of the female reproductive organs was investigated. A total of 60 female albino rats of the Wister Strain were randomly divided into 12 groups of 5 rats each (group’s 1-12). Groups 1 and 2 served as the control groups and were administered normal saline and dimethylsulfoxide (DMSO 5 mg kg-1 body weight), respectively for 14 days. Groups 3-7 were administered 10, 25, 50, 75 and 100 mg kg-1 body weight of aspirin respectively for 14 days while groups 8-12 received 2.0, 2.5, 3.0, 3.5 and 4.0 mg kg-1 body weight of indomethacin respectively for 14 days. At the end of the 14 day, the animals were sacrificed and the ovary, uterine tubes and uterus obtained for routine histological processing and subsequent histopathological assessment. Results from this study showed normal histological profiles of all organs obtained from the rats in the control groups while the experimental groups treated with aspirin and indomethacin presented with vasoconstriction in the ovary and atrophy of smooth muscles of the uterine tubes and uterus. This study has establish to some extent, the vasoconstrictive potency of aspirin and indomethacin and thus providing an experimental basis for the use of these drugs to reduce and if possible stop ovarian and uterine hemorrhage but further investigation to elucidate the vasoconstrictory effect, smooth muscle atrophy and the reversibility of some of the toxic effect of these drugs on the female reproductive organs and the mechanism involved is recommended in further studies.