Abstract: The hepatoprotective activity of ethanol (95%) extract of (250 mg kgG-1) Cansjera rheedii J. Gmelin whole plant was evaluated against paracetamol induced hepatotoxicity by evaluating biochemical parameters such as Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP), Total bilirubin, Total Protein and Gamma Glutamate Transpeptidase (GGTP). A 10% of liver homogenate was used for estimation of enzyme such as Superoxide Dismutase (SOD), Glutathione S-Transferase (GST), Lipid Peroxidase (LPO) and Glutathione Peroxidase (GPx) for antioxidant study. Treatment of rats with ethanol extract significantly (p< 0.001) altered serum marker enzymes and antioxidants level near to normal against paracetamol intoxicated rats. Silymarin (50 mg kgG-1, p.o.) used as control.