Abstract: Generalized abnormalities in glycoprotein metabolism are reported in both naturally occurring and experimental diabetes. The effect of Aloe vera, a traditionally used plant for the treatment of diabetes mellitus, was examined in Streptozotocin (STZ)-induced diabetic rats on derangement in glycoprotein’s levels. STZ injection (55 mg kg-1 body weight) caused massive alterations of glycoprotein components such as hexose, hexosamine and sialic acid in plasma and tissues (liver and kidney) of diabetic control and experimental groups of rats. Oral administration ethanolic extract of Aloe vera leaf gel extract (300 mg kg-1 body weight) for 21 days significantly restored the levels of hexose, hexosamine and sialic acid to near normalcy. These effects were compared with glibenclamide, a reference drug. Thus, the present study confirms that Aloe vera gel extract possesses a significant beneficial effect on glycoprotein components in STZ-induced diabetic rats, thereby preventing glycoprotein’s mediated secondary diabetic complications.