Abstract: The venom of the Lapemis curtus was tested for its ability to induce histopathological changes in mice intraperitoneal injection of the venom (LD50 of 0.65 mg kg-1), by light microscopic examination of some organs (liver, kidney and spleen). L. curtus venom induces changes including necrosis and edematous appearance with cellular infiltration and vacuolation. The injury of kidneys includes significant changes of the glomerular apparatus. Venom treated mice liver shows congestion, micro vesicular fatty changes and infiltration of inflammatory cells around the portal vein. Where as, spleen showed hemorrhage, congested and inflammation were observed. Areas of hemorrhage, vascular congestion and cloudy swelling in renal tubules were observed in the kidney. No myoglobinuria was noted in any group of animals. The crude venom was also administered intraperitoneally into the experimental animals and tissue samples were taken at several time intervals. The venom of the sea snake L. curtus, was tested for its ability to induce myonecrosis changes in albino mice. Induction of myonecrosis was demonstrated by their ability to release Creatine Kinase (CK) from damaged muscle fibers and direct histopathological examination of the injected muscles (i.m.). Crude venom exhibits intense myonecrosis characterized by the changes including, necrosis and edematous appearance with cellular infiltrate, vacuolation and degenerated muscle cells with delta lesions and heavy edema in between the cells.