Abstract: The present study determined the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 and C4, in the blood serum of patients with FMF and assess the influence of colchicine medication on these parameters. No significant changes in the total hemolytic activity of the complement and the activities of C1, C4, C3 and C2 complement components were found between the healthy subjects and those FMF patients, who received regular colchicine treatment. On the contrary, the total hemolytic activity of the complement and C1, C2, C3 and C4 hemolytic activities in the serum of colchicine-free FMF patients were significantly higher than in the healthy subjects. In the serum of those patients, who received irregular colchicine treatment, significant changes were detected only in case of the total hemolytic activity of the complement and the hemolytic activity of C2 complement component: both parameters were higher than those of healthy subjects. Our results demonstrate that regular colchicine treatment results in suppression of the complement classical pathway functional activity in FMF patients, suggesting about possible anti-inflammatory effect of colchicine and confirm the efficiency of regular colchicine treatment.