Abstract: Few new 2-[(1-phenyl-1H-pyrazolo [3,4-d] pyrimidin-4-yl) oxy]-N`-(4-aryl-1,3-thiazol-2-yl) acetohydrazide derivatives have been prepared and characterized by analytical and spectral analysis. The newly synthesized compounds have been screened for their analgesic activity. Some of the compounds have exhibited excellent analgesic activity.