Abstract: The objective of the research was to study the response of acid-adaptive soybean lines in Ultisols and Vertisols soil types. Nine acid-adaptive soybean lines were grown on Ultisols in Sumatera Island and on Vertisols in Java Island. The design was randomized complete block design with three replications. Results showed that all the observed characters were affected by different soil types, except plant height. Genotype×environment interaction was found on number of pods plant–1 and grain yield. In Vertisols, some of agronomical characters increased such as days to maturing, number of branches plant–1 , number of filled pods plant–1, grain size and grain yield but one agronomical character, plant height, decreased. Increasing grain size was found in most of the genotypes grown in Vertisols. A positive correlation was found between grain size and grain yield that described increasing grain yield caused by grain size. Two genotypes G2 and G8 achieved the highest grain yield up to 2.54 and 2.48 t ha–1 in Vertisols suggesting these genotypes can be developed in this soil type.