Abstract: Crude ethanol and aqueous extracts derived from different parts (i.e., leaf, flower, stem and pod) of Senna spectabilis and S. tora were tested in vitro against Escherichia coli, Bacillus cereus, Candida albicans and Saccharomyces cerevisiae. It was shown that only crude water extracts of S. spectabilis could inhibit the growth of B. cereus (20-25 mm, diameter of the clear zone). In contrast, both crude ethanol and aqueous extracts of S. tora were active against E. coli growth (6-10 mm) and only crude water extracts of S. tora were able to inhibit the S. cerevisiae growth. However, none of these crude extracts could inhibit the growth of C. albicans.