Abstract: Ethno-floristic studies of Ethiope Council area of Delta State, Nigeria was carried out with a view to take inventory of the flora and establish the varying ways plants are used by the aborigines. A total of 145 plant species distributed into 51 angiosperm families were recorded in the area. The studies indicate that the indigenous people have developed various ways and methods for the utilization of their plant resources. Efforts were made to track and document the customary knowledge and use of these plants. The information is intended to contribute to the current global efforts at safeguarding the loss of indigenous values and knowledge of biological resources.