Abstract: Plants and plant products are continuously being explored in medicine against free radicals induced oxidative stress and increasing No. of antibiotic resistant organisms. In the present study antioxidants and antimicrobial activity of methanol leaf extract of N. laevis and Crateva adansonii against some pathogenic microorganism were carried out. The antioxidants activities were conducted using DPPH radical scavenging assay. The antibacterial activity was screened against Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and E. coli using agar well diffusion method at various concentrations (160, 120 and 80 mg mL–1). The Minimum Inhibitory Concentration (MIC) was determined using serial dilution method, while Minimum Bacterialcidal Concentration (MBC) by plating various dilution of extract. Results revealed the presence of alkaloid, flavonoids, saponins, terpenoids, glycoside and anthraquinone in methanol leaf extract of N. laevis. Newbouldia laevis and Crateva adansonii extracts and the standard antioxidant (Vitamin E) promoted an inhibition of DPPH radical with increasing concentrations. The IC50 values of C. adansonii, N. laevis and Vitamin E were 1562.52, 155.17 and 83.65 mg mL–1, respectively. The zone of inhibition demonstrated by the two extracts increase with increase concentration. The MIC of both extracts was in range of 120-160 mg mL–1, while the MBC range between 120-160 mg mL–1. It is concluded that N. laevis contains some useful phytochemicals with potential antioxidants and antibiotic reputations. Thus, it may be considered as a natural source of antimicrobials and antioxidants for therapeutic purposes.