Abstract: Background and Objective: Human filariasis are important tropical diseases world-wide. Certain types of zoonotic filariasis may also be transmitted to humans in climate zones cooler than the tropics. The aim of this study was to determine the prevalence of human onchocerciasis. Materials and Methods: The study was carried out in a portion of the Sanaga river located in the Sanaga valley from Edea in the forest area to Mbakoau in the Savannah area. Eight villages namely Mbebe, Nyanon-Kikot, Nyannon-Binoum, Ntol, Ntol-Lenouck, Bonepoupa, Ombe and Mbakaou were selected. In each of the 8 villages chosen, a sample of the population was admitted following the inclusion and exclusion criteria. A total of 609 persons were examined during the period of this study. Data was analyzed using Chi-Square statistics. The frequencies were calculated and presented on tables. The p<0.05 were considered significant. Results: A total of 11(1.8%) persons had mansonellosis. Most of these were from the transition habitat type. Eighty-six (14.1%) presented with common signs of epilepsy with higher percentages recorded in persons in the transition habitat type and among those above 10 years old. Studying the association of the various diseases, the results gave higher prevalence for epilepsy among people infected with onchocerciasis. Conclusion: Onchocerciasis, Malaria and Epilepsy appear to be of primary concern thus something must be done by health authorities and other sectors responsible for public health issues, in order to effectively control these insect-borne diseases and the nuisance they cause.