Abstract: Background and Objective: Soil transmitted helminthes (STH) infection affect more than two billion people worldwide with Nigeria having the highest burden in Sub-Saharan Africa. This study examined the spatial and potential distribution of STHs in Nigeria. Materials and Methods: Secondary data for the prevalence of Ascaris lumbricoides, Trichuris trichiura and hookworms in Nigeria contained in 98 journal publications were extracted and used in determining the spatial distribution of the parasites using DIVA-GIS software. A total of 19 bio-climatic and topographical variables grouped into 3 main variables namely: temperature, precipitation and altitude were used in the modeling of the potential distribution of the parasites using Maximum Entropy (MaxEnt) modeling tool. Results: The average prevalence of A. lumbricoides, Hookworms and T. trichiura in Nigeria were 25.17, 16.86 and 9.74%, respectively. Delta State (62.08%) had the highest prevalence for A. lumbricoides followed by Oyo (55.50%) and Kano (44.40%) while 14 states had prevalence of below 20.0%. Akwa Ibom and Kano States had the highest average prevalence of 55.80% for hookworm infections. Delta, Oyo and Benue States had prevalence of 38.08, 35.80 and 35.40%, respectively while 22 states had prevalence of hookworm below 20.0%. T. trichiura had the least average prevalence among the three STHs. Akwa Ibom State had the highest prevalence for this parasite with 40.40% followed by Lagos, Delta and Kwara States with prevalence values of 24.85, 24.05 and 23.37%, respectively. Other states in the Federation had prevalence values of less than 12% with Federal Capital Territory (FCT) Abuja and Borno State having the least prevalence of 0.80 and 0.90%, respectively. The potential distribution reveals that southern Nigeria has been at high risks of infection. Precipitation of the wettest month, altitude and precipitation of the warmest quarter are the major environmental variables that affect the distribution of STH. Conclusion: All states in Nigeria are endemic for STHs. Southern Nigeria has higher prevalence of STHs than Northern Nigeria. The prevalence distribution is determined by temperature, precipitation and altitude.