Abstract: Dogs are pivoted in Echinococcus granulosus (E. granulosus) transmission to human that causes cystic echinococcosis. Uses of effective drugs as chemoprophylactic or chemotherapeutic provides a very practical and an important prevention strategy to control programs in endemic countries. The aim of the present study was to determine the effect of flubendazole (FLBZ) on E. granulosus infection in dogs as a chemoprophylactic and chemotherapeutic. FLBZ was given by a dose of 20 mg kg-1 twice daily 35 days post infection for 3 consecutive days and was given by the same dose at time point of infection for 15 consecutive days. The results of the chemoprophylactic effect and chemotherapeutic effects showed significant reduction in the number of worms according to control group, also there was marked inhibition of maturation that gave 84.9% for FLBZ chemoprophylaxis and 100% as chemotherapeutic. SEM studies revealed different changes in the adults parasites surface.