Abstract: This study has investigated the potency of traditional medicinal plants such as Allium sativum (garlic) and Commiphora molmol derivative (Mirazid) for treating schistosomiasis and the liver granuloma formation. The effects of garlic and mirazid on Schistosoma mansoni infected mice were examined by liver enzymes, counting worm burden, schistosome egg load, modulation of the granuloma and histopathology of the liver injury. The use of garlic or mirazid or combination of them led to marked reduction in worm load (43, 52 and 70%, respectively), ova deposition (43, 59 and 83%, respectively), size and number of granuloma (38, 46 and 67%, respectively) in the liver of mice infected with schistosoma. Also, these treatments ameliorated the histopathological injury changes of the liver and physiological assays of AST, ALT and total bilirubin. These findings indicate that garlic, mirazid and a combination of them have anti-schistosomal activity in mice. All of them significantly reduced the production of eggs output in S. mansoni infected mice. In addition, garlic and mirazid combination clearly reduced the liver granuloma size which was reflected by the degree of improvement in the status of the liver. To our knowledge, this study is the first in using the combination of garlic and mirazid in schistosomal treatment in mice.