Abstract: Mosquitoes are vectors of etiologic agents of malaria, filariasis and viral disease. Anopheles stephensi Liston (Diptera) is the primary vector of malaria in India and other West Asian countries and improved methods of control are urgently needed. In the present investigation the effect of certain plants on the larval mortality, biology and biochemical parameters of Anopheles stephensi were studied. Ten medicinal plants were collected, dried and extracted with methanol and used for the present study. Out of ten plants tested 100% mortality of Anopheles stephensi was observed in four plants namely Albizia amara, Areca catechu, Leucas aspera and Ocimum sanctum after 24 h treatment. The pupation and adult emergence was appeared to be dose dependent (1, 3 and 5% of extracts). The treated larvae showed reduction in the levels of carbohydrate, DNA and RNA when compared to the control which proved that the vector management is possible by using different medicinal plants. The medicinal plants were easily biodegradable than the synthetic insecticides, the plant products are less hazardous; they afford a rich storehouse of chemicals of diverse biological activities.