Abstract: A study of three plants traditionally used in the treatment of malaria in the Southeastern part of Nigeria was investigated to determine their efficacies as antimalarial compounds. The three herbs were collected through a traditional herbalist who uses them in his practice. Ethanolic extracts from the roots of Enyim ocha (Salacia nitida), Ovoro ilu (Nauclea latifolia) and stem bark of Erumeru (Enantia chlorantha Oliv.) were assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei in mice using the 4 day suppressive test procedure. The extracts had intrinsic antimalarial properties that were dose dependent. The comparison analysis indicated that 250 mg kg-1 body weight of the root of S. nitida produced 71.15% suppression of parasitaemia and the 500 mg kg-1 body weight of the stem bark of E. chlorantha, roots of S. nitida, N. latifolia and the three herbs combined, produced 75.23, 73.28, 71.15 and 77.46%, respectively, compared with chloroquine with 71.15% suppression. The results were significant at p< 0.05 when compared to a placebo and support the traditional use of these plants for the treatment of malaria.