Abstract: Background and Objective: Tuberculosis is at the top of health problems in the various regions of Sudan, where this disease is associated with poverty and poor environmental and health conditions. Therefore, it spreads among poor communities as well as the displaced. The present study aimed to study patterns of tuberculosis infection. Materials and Methods: A retrospective cross-sectional descriptive hospital-based study of all tuberculosis patients (n = 1252) who had TB admitted to the department of respiratory tract diseases at the El-Obeid Teaching Hospital from 2015-2017. It was carried out from February to December, 2018. Data entered, processed and analyzed using the Statistical Package of Social Sciences (SPSS) version (16.0) and Microsoft Excel (2010) software. Results: The (31.2%) of tuberculosis patients had suffered from extra-pulmonary and (68.8%) of them had a pulmonary pattern. TB reached its peaked at the age 21-40 years with (44.3%), followed by 41-60 years with (22.5%). It responsible for the in-hospital mortality rate was (12.2%), (11%) and (15%) were responsible for pulmonary and extrapulmonary tuberculosis. There was a highly significant relationship between socio-demographic factors (age and gender) and the etiological diagnosis (p = 0.001 and p = 0.000). Conclusion: All data about patients admitted to the department of respiratory tract diseases should be listed in an accurate mode using uniform records. There is a need for early detection and treatment of TB cases so as become possible to provide optimal health care and decrease mortality rates.