Abstract: Background and Objective: The association between psychiatric disorders and H. pylori functional dyspepsia remains controversial. To determine the prevalence of psychiatric disorders in patients with H. pylori infections and assess the effect of antidepressant drugs on the relief of Functional Dyspepsia (FD) symptoms and eradication of H. pylori. Materials and Methods: The H. pylori diagnosis was done by using stool Ag detection and biopsies during endoscopic examination. The psychiatric status of H. pylori patients was evaluated using the Hamilton Anxiety Rating Scale (HAM). The effect of standard quadruple therapy was compared versus added antidepressant drugs in patients with psychiatric disorders. All patients’ records were checked for H. pylori eradication and improvement of severity of FD symptoms for six months. Results: H. pylori was positive in 53 patients (55.2%). The majority of H. pylori patients were females <50 years old. About 52.8% of H. pylori patients had psychiatric disorders. The most common psychiatric disorder was anxiety in 19 patients (67.9%) and 9 patients (32.1%) were diagnosed with depression. Twenty-six out of twenty-eight patients (92.9%) who received antidepressant treatment plus the standard quadruple regimen, had successful treatment outcomes at 4 and 5 weeks. While only 14 out of 25 patients who received the standard quadruple regimen (56%) had successful treatment outcomes at 4 and 5 weeks. Conclusion: High prevalence of H. pylori infections in the Kingdom of Bahrain. There is a clear association between psychiatric disorder and H. pylori infection. Added antidepressants drugs to standard antibiotic regimen may have a role in the improvement of FD symptom and H. pylori eradication.