Abstract: Background and Objective: Cervical radiculopathy (CR) is a nerve root pathology that causes chronic physical and psychological disabilities. The aim of this study was to investigate the effectiveness of adding cognitive behavioral therapy (CBT) to standard physical therapy program to study the short and medium term effects in patients with chronic CR. Materials and Methods: Sixty patients from both gender between 45 and 65 years who were diagnosed with chronic spondylotic CR were assigned randomly into two groups: Group A (control group): 30 patients received a physical therapy program of manual therapy (MT) and therapeutic exercise (TE) for 18 sessions over 6 weeks period (3 sessions/week). Group B (study group): 30 patients received the same program as in Group A plus CBT. Arabic neck disability index (ANDI), Arabic pain anxiety symptoms scale (APASS) and right/left side-bending (Lt/Rt SB) range of motion (ROM) were measured at baseline, post intervention and at 6 months for follow up. Results: Mixed MANOVA for effect of treatment on mean values of NDI, PASS and Rt/Lt SB for Groups A and B exposed that there was a significant difference for post-treatment and 6 months follow up as compared with pre-treatment. Multiple pair wise comparisons determined the difference between both groups, for pre-treatment, there was no significant difference, but for post-treatment and follow up there was a significant improvement in study Group B than control Group A as p-value was 0.0001. Conclusion: A multimodal approach of CBT combined with physical therapy program of manual therapy and therapeutic exercise yielded greater improvement among pain anxiety, neck disability and cervical ROM in the short and medium term effects in comparison with physical therapy alone.