Abstract: Background and Objective: Explosive power movement in a 200 m race will potentially yield free radicals. The energy source of a 200 m runner, based on his movement, comes from anaerobic predominant metabolism, which also potentially yield high lactic acid. The increase in lactic acid causes the decrease in pH which tends to suffer from acidosis so that the establishment of ATP is hampered and cause pain in muscles. This condition can influence the performance of the 200 m runners. The objective of the research was to find out the influence of combination of weight training with sport massage, on the change in glutathione peroxides (GPX) and lactic acid elimination in the 200 m runners. Materials and Methods: The research used experimental method with pre and post test design. The research subjects were 20 students of Faculty of Sports Science, Medan State University, who had not been trained as 200 m runners and had fulfilled the inclusive and exclusive criteria, taken by using random sampling technique. Students were divided into two groups: WT+SM (Combination of weight training with sport massage) group and WT-SM (weight training without sport massage). The treatment was performed in 8 weeks with the frequency of exercise 3 times a week. Results: The research showed that there was significant influence of the treatment (p<0.05) in the pre and post treatment in the WT+SM group and in the WT-SM group on the mean value of increase in glutathione peroxides content and the mean value of decrease in lactic acid content in 200 m runners. There was no significant difference (p>0.05) of the increase in glutathione peroxides in 200 m runners in the post treatment done by WT+SM group and by WT-SM group. There was significant difference (p<0.5) in the mean value of decrease in lactic acid content in the 200 m runners in the post treatment done by WT+SM group and by WT-SM group. Conclusion: Combination weight training with sport massage was better in increasing glutathione peroxides content and decreasing lactic acid content in the 200 m runners than that of only weight training.