Abstract: The objective of study was to determine the correlation of septal body and the quality of life-based on sinonasal outcome test (SNOT-20). The potential role of the septal body in inducing the nasal obstruction is important because it can be expanded as an effect of nasal septum deviation. This study was using cross-sectional design method. The quality of life of 70 samples patient with nasal septum deviation was measured with SNOT-20 and the coronal plane of paranasal sinuses CT scan then continued with the measurement of nasal septum deviation degree, septal body’s direction and size. Data analysis was performed using bivariate and partial correlation test using SPSS. Statistical analysis confirmed that there were significant correlations between nasal septal deviation levels with the size of the septal body (p<0.05). The degree of nasal septum deviation had a positive correlation with the size of contralateral and had a negative correlation with the size of ipsilateral of the septal body. Nasal septum deviation and the size of ipsilateral of the septal body had a significant correlation with the quality of life in middle position (p<0.05) based on bivariate and partial correlation test. There was a correlation between the degrees of nasal septum deviation with the size of ipsilateral and contralateral of the septal body and they were correlated with the quality of life in a medial position of the septal body.