Abstract: One of the most important anti-inflammatory protein is adiponectin. It acts to prevent the deleterious of TNF-α on endothelial cell by reducing level of adhesion molecules. To investigate the correlation between serum tumor necrosis factor (TNF)-α, high sensitivity C-reactive protein (hs-CRP) and adiponectin level in coronary artery (CA) and those in the radial artery (RA). This study also sought to investigate the association of those results with epicardial adipose tissue (EAT) in coronary artery disease subjects. A cross-sectional study of 110 Indonesian subjects who underwent transthoracic echocardiography (TTE) and diagnostic coronary angiography were studied. Blood samples from RA and CA were collected before coronary angiography. Pearson correlation analysis was used to determine the relationship between mean values and all statistical analysis was done by using SPSS. This study found forty three subjects with severe coronary artery disease (CAD) and thicker EAT (8.5+6.9 vs 6.1+2.6, p<0.001). Analysis of the correlation between serum level of TNF-α in RA versus CA showed for linear correlation in non-severe CAD (r = 0.57, p<001), severe CAD (r = 0.67, p<001) and all subjects (r = 0.61, p<0.001). Serum level of hs-CRP showed strong correlation for non-severe CAD (r = 0.99, p<0.001), severe CAD (r = 0.98, p<0.001) and all subjects (r = 0.99, p<0.001). Furthermore, analysis of serum level of adiponectin for non-severe CAD (r = 0.87, p<001), severe CAD (r = 0.86, p<0.001) and all subjects (r = 0.86, p<0.001) also showed linear correlation in both sample site. A linear correlation between TNF-α, hs-CRP and adiponectin in RA and CA associated with EAT in CAD subjects.