Abstract: Psoriasis is a very commonly seen inflammatory condition in skin clinics. It has been suggested that this disease is associated with metabolic disease, particularly abnormalities in serum lipid profile. This study sought to examine possible association between plaque-type psoriasis and some individual variables of metabolic syndrome. After being approved by an ethical committee, 53 patients with plaque-type psoriasis were recruited along with 55 age and sex-matched healthy individuals as controls. The status of smoking, alcohol consumption and lipid profile including abnormally increases serum total cholesterol, Low Density Lipoprotein (LDL) and triglyceride, hypertension, diabetes mellitus and overweight/obesity were compared between the two groups. The case group was consisted of 27 males and 26 females with a mean age of 47.89±8.09 years. The controls were 35 males and 20 females with a mean age of 48.38±7.46 years. Smoking (43.4 vs. 20%, p = 0.01), increased serum total cholesterol (43.4 vs. 14.5%, p = 0.001), increased serum LDL (34 vs. 12.7%, p = 0.01) and hypertriglyceridemia (43.4 vs. 12.7%, p<0.001) were significantly higher in patients than in controls. These differences remained significant after logistic regression analysis. The two groups were comparable in terms of age (p = 0.74), sex (p = 0.18), alcohol consumption (p = 0.56), overweight/obesity (p = 0.74), hypertension (p = 0.33) and diabetes mellitus (p = 0.60). In conclusion, this study showed a significant association between smoking and abnormal lipid profile with psoriasis. Screening/preventive programs are recommended in this regard.